Swine Health - PRRS
Evaluation of a novel anti-idiotype vaccine against PRRSV infection
March 27, 2007By Jeffrey Zimmerman
The primary objective of this project was to test a PRRS vaccine based on a PRRSV anti-idiotypic antibody. Subsequent to the primary objective, the intent was to determine whether effective vaccines...
Swine Health - PRRS
Physical Characterization of the PRRSV Virion
March 23, 2007By Michael Murtaugh
The research here shows that PRRSV grows in cells as a population of viruses with the same shape, the same RNA molecules, and the same protein composition. There was no evidence for multiple forms...
Swine Health - PRRS
Mechanisms of Failed Protection Against PRRS in Sow Herds
February 28, 2007By Michael Murtaugh
We have established a set of standard protocols and reagents for whole genome PRRSV sequencing and assembly. Phylogenetic comparisons amongst 10 pairs of homologous strains confirmed several regions...
Swine Health - PRRS
Investigation into the ability of the anti-idiotype to block PRRS virus infection and characterization of a putative receptor on MARC-145 cells and porcine alveolar macrophages
November 25, 2006By Jeffrey Zimmerman
PRRS is the most costly disease U.S. swine producers confront and little progress has been made in recent years to improve the situation. Prevention and control of PRRS has been difficult, in part...
Swine Health - PRRS
Implementation of a PRRSV Strain Database (Renewal)
November 7, 2006By Kay S. Faaberg
A PRRSV ORF5 database, accessible worldwide, was improved for swine producers, practitioners and researchers (http://prrsv.ahc.umn.edu/). This database, established to fulfill one objective of the...
Swine Health - PRRS
ub-typing of PRRSV isolates by means of measurement of cross-neutralization reactions
November 3, 2006By Fernando Osorio
One of the major obstacles for PRRSV control is the significant variability of this virus in the field. Such variability of PRRSV is expressed at the level of the genetic information of the strains (...
Swine Health - PRRS
Analyzing PRRS status of piglets on multiple farms after serum exposure to validate production of negative piglets
November 3, 2006By Jeff Feder
Based on these results, serum exposure can be an effective way of stabilizing a sow herd and weaning negative piglets on a consistent basis in large, commercial sow units faced with a variety of PRRS...
Swine Health - PRRS
Development and Optimization of a Blocking ELISA for Type 1 and Type 2 Strains of Porcine Reproductive and Respiratory Syndrome Virus
November 1, 2006By Christopher Chase
The NPB Initiative recognizes that the most effective way to control PRRS is to eliminate the virus from domestic swine herds. Control and elimination strategies should include diagnostic tools that...
Swine Health - PRRS
Accurate ELISA test development: Evaluation of cysteine protease domain of non-structural protein 2 as a potential antigen
October 31, 2006By Ying Fang
Currently, in the absence of effective vaccines and therapeutic drugs, one of the key approaches to achieve the “National PRRS Elimination” is to identify PRRSV infected pigs, so such...
Swine Health - PRRS
An Improved Method for PRRSV Surveillance and Monitoring
October 11, 2006By Jeffrey Zimmerman
Oral fluids are inexpensive to collect. Each pen sample requires a length of cotton rope, a plastic bag, and a snap-cap plastic tube. Labor costs include the time required to place and recover the...